Overview and History

Plaquenil generic (also referred to as Hydroxychloroquine / Hydroxychloroquine Sulfate) originates from a group of drugs called antimalarials. Its basic function is prevention or treatment of malaria, an infection of red blood cells transmitted through the mosquito bite. Nevertheless, Plaquenil is not applicable to cure severe cases or complicated types of malaria. Plaquenil is can also be referred to as a disease-modifying anti-rheumatic drug (i.e., DMARD). Plaquenil is applied for treatment of discoid lupus erythematosus (DLE) as well as systemic lupus erythematosus (i.e., lupus or SLE). In addition, Plaquenil is also applicable to cure severe and chronic rheumatoid arthritis, since it is able to reduce the swelling and pain caused by arthritis, as well as prevent damage of joints and minimize the risks of disabilities in a long term.

Plaquenil belongs to a class of drugs that were initially utilized for prevention and treatment of malaria. Nowadays, this medication is applied to cure certain lupus symptoms, rheumatoid arthritis, childhood arthritis (also known as juvenile idiopathic arthritis) as well as other autoimmune diseases. The reason why Plaquenil is effective for treatment of autoimmune diseases is yet to be confirmed by clinical studies and numerous researches. Based on theory, Plaquenil is able to interfere the communication of cells of the immune system and fight the virus.

Current studies suggest that Plaquenil is to be applied for COVID-19 treatment only in a hospital or as part of clinical trials. Hereby, you are not advised to take Plaquenil unless there is a corresponding prescription from your healthcare provider.

Plaquenil generic (Sanofi) Immune PharmaceuticalsCanadian Pharmacy Plaquenil Prices (200mg and 400mg)

  • 200mg x 20 tablets = $24.99
  • 200mg x 30 tablets = $34.99
  • 200mg x 90 tablets = $85.99
  • 400mg x 30 tablets = $56.99
  • 400mg x 60 tablets = $103.99
  • 400mg x 90 tablets = $141.99

Manufacturers in US:

  • Sanofi‐Aventis
  • Concordia
  • Sandoz
  • Laurus Labs
  • Accord Hlthcare
  • Amneal Pharms
  • Mylan
  • Lupin ltd
  • Teva Pharms

Manufacturers in Canada:

  • Apotex inc.

Other Generic Names:

  • Hqtor
  • Hydroquin
  • Oxcq
  • Qyn
  • Rhq
  • Rutor
  • Zhquine

Main Alternatives:

  • Methotrexate
  • Enbrel

Recommended Dosage and Administration of Plaquenil Generic

Plaquenil is to be administered in a strict accordance with directives from by your healthcare specialist. Abstain from varying the recommended dose, or frequency of drug administration, as well as overall duration of treatment suggested by your physician. Plaquenil tablet is to be swallowed as a whole. Avoid crushing, breaking, or chewing Plaquenil tablet. Plaquenil is allowed to be taken with meals in order to minimize occurrence of stomach upset, unless your doctor suggests otherwise. Once the treatment course with Plaquenil has started, the patient is required to complete it without any interruptions, even if there are improvements in health conditions, unless advised otherwise by doctor. If the treatment is stopped earlier than suggested, the infection has a risk of not stopping completely.

Plaquenil is available in a tablet form for oral administration. Adult dosage for rheumatic diseases may vary from 200 mg/day to 400 mg/day (generally, 5 mg/kg, with maximum daily dose of 400 mg). In specific situations, higher doses can be prescribed, provided there are no contraindications. Plaquenil can be administered as a single dose per day or split in 2 doses if more than 1 tablet is taken. Symptoms may start showing signs of improvement within 1-2 months, however it may require up to 6 months in order to observe complete benefits of this drug. Various diseases may require different dosage of Plaquenil, hence before initiating any treatment, make sure to consult with your healthcare specialist and define the most suitable and safe dosage.

Any missed dose of Plaquenil should be compensated and taken as soon as possible. Nevertheless, if the missed dose was observed within a short time before the next dose, it is suggested to skip the missed dose and proceed with regular schedule of dosage. Abstain from doubling the dose in order to compensate a missed dose.

Summary of Possible Side Effects

Plaquenil generally is quite well-tolerated by the body. There are no adverse side effects frequently observed. The most commonly occurring side effects include diarrhea and nausea, which generally improve over time. Less common side effects may include changes of skin pigmentation (e.g., darkening or occurrence of dark spots), rashes, changes related to hair, muscle weakness and others. Rarely observed side effects caused by Plaquenil may include anemia, which may appear among few patients, who have a condition called porphyria or G6PD deficiency.

In rare cases, Plaquenil can result in visual alterations or vision loss. These vision issues are most probably occurring in patients, who take high doses over a long period of time, as well as patients, who are 60 years old and above, and patients suffering from severe kidney/liver disease or underlying retinal disease. The recommended dosage generally does not contribute anyhow to development of any visual conditions. However, it is still recommended to undergo an eye examination during the first year of Plaquenil treatment, with subsequent repetition for every 1-5 years.

Moreover, there are some rare occasions of alterations in the heart rhythm, caused by Plaquenil in combination with other drugs. Any hearth rhythm issues should be reported directly to healthcare specialist and evaluated only after hospitalization.

Precautions, Contraindications, Interactions of Plaquenil Generic

Even though there are not so many drug interactions with Plaquenil, it is still required to inform your healthcare provider about the complete list of medications that you are taking (including natural medicines and over-the-counter meds), before initiation of Plaquenil treatment.

Administration of Plaquenil alone or with in combination with other drugs (e.g., azithromycin) may increase the risks of heart rhythm issues (e.g., ventricular fibrillation, QT prolongation, ventricular tachycardia etc.).

If you are concurrently being observed by other doctors, make sure you inform them about start of Plaquenil treatment. Plaquenil does not exert have a serious effect on immune system, hence vaccines suggested by other doctors are usually allowed. Inform your oculist if you are taking Plaquenil, so that he schedules regular visual screening tests for you. Any pregnant, about to become pregnant soon, or lactating patients are required to consult with healthcare specialist prior to taking Plaquenil, even though Plaquenil has reported to be safe during the periods of breast feeding and pregnancy.

Plaquenil is to be stored at room temperature, in a closed container away from sources of moisture, heat, and direct light. Abstain from freezing and keep Plaquenil away from of children. Do not store outdated Plaquenil or if it is no longer required.

Comparative Analysis of Plaquenil and Ivermectin as COVID-19 Treatment

Plaquenil is an antimalarial medication, analogous to chloroquine (CQ), deemed more as an immunomodulator rather than immunosuppressant. Plaquenil and CQ are able to inhibit SARS-CoV-2 in vitro, whereas Plaquenil appears to remain more potent than chloroquine (CQ). Plaquenil has reported antiviral effects during both pre-infection and post-infection stages. Likewise, Plaquenil is able to interfere with the glycosylation process of angiotensin-converting enzyme 2, hereby decreasing the efficiency of binding between angiotensin-converting enzyme 2 on host cells as well as the SARS-CoV-2 spike protein. In addition, Plaquenil may also be able to block the fusion of virus with the host cell via inhibition of protease activity inside cleaving coronavirus surface spike proteins.

Plaquenil also reports the ability to suppress the ‘‘cytokine storm’’ accountable for the progression of disease to acute form of respiratory distress syndrome via numerous mechanisms, which include the decrease of T-cell differentiation and activation, as well as reduction in generation of cytokines by B cells and T cells. There are some ongoing studies in vivo to evaluate Plaquenil efficiency in case of SARS-CoV-2 infection, and as of now they already have some preliminary results, which are quite promising.

Ivermectin (product page) belongs to an antiparasitic medications group, generally prescribed by dermatologists as an initial treatment for cutaneous larva migrans. Notably, Ivermectin has also shown some antiviral activity, while acting as a special inhibitor of importin-alpha/beta-mediated type of nuclear import. Hence, by influencing importin-alpha/beta-dependent nuclear transport of viral proteins, Ivermectin is able to suppress the replication process of some RNA viruses, like chikungunya virus, yellow fever virus, as well as HIV.

Some recent studies have shown antiviral features of Ivermectin in treatment of the SARS-CoV-2 clinical isolate in vitro, whereas a single dose of Ivermectin could control replication of virus during 24-48 hours after administration. Though not yet concluded, it is believed that such outcomes could be caused by the inhibition of importin-alpha/beta1-mediated nuclear import inside viral proteins (like in RNA viruses). However, there was no complete study of Ivermectin in vivo application conducted.

Likewise, all the abovementioned studies and results draw a conclusion that Plaquenil and Ivermectin may be able function in a synergistic and consequential manner. Basically, Plaquenil could act as a first-level barrier via inhibition on the virus penetration inside the host cell, whereas Ivermectin could decrease viral replication if the virus managed to penetrate, while strengthening antiviral effects of Plaquenil. Plaquenil is relatively inexpensive from manufacturing point of view and quite safe if treatment is properly observed and controlled. Ivermectin appears to be safe and easily tolerated, without any adverse drug-imposed effects. In addition, both mediations do not appear to have any adverse drug interactions. However, it is important to point out that no in vivo or in vitro studies have been conducted yet to confirm the effect of combining Plaquenil and Ivermectin to successfully treat SARS-CoV-2 infection. Hence, any administration of Plaquenil requires prior consultation with healthcare provider, as well as strict adherence to prescription and continuous monitoring in order to ensure effective treatment outcomes.


Disclaimer

All information that you can find here about Plaquenil, its consumption, and dosages, is offered for education. We don’t bear responsibility for the details provided in this article and encourage you to consult a medical specialist if you want to take this drug. A doctor can properly assess your medical history and conclude whether Plaquenil is safe for you. Taking this drug without physical examination and consultation with a doctor can cause various side effects. The article doesn’t provide all the information you need to determine whether it’s right for you.